Tech ID: 17.625
Researchers at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing have cloned and characterized a QTL in rice that is alone responsible for a “new plant type” (NPT) rice crop ideotype with distinctive architecture, having larger panicles, fewer sterile tillers, stronger culms and higher yield. This gene encodes a deubiquitinating enzyme, OTUB1, never before associated with a phenotype in plants but which is highly conserved across plants and other species. Reducing the expression or activity of OTUB1 (though not its complete loss) increases grain yield via effects on a number of important yield component traits. This opens the way for increased crop yields using a variety of strategies, including genome editing, and in a range of crop species.
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Published: WO 2018/215779; AR Patent Bulletin No. 1056; EP 3634984; BR Journal 2580; CN 111032684A; EA 201992790A1; IN 201917053571A; US 2021-0017532
Shuansuo Wang et al (2017). Non-canonical regulation of SPL transcription factors by a human OTUB1-like deubiquitinase defines a new plant type rice associated with higher grain yield. Cell Research; 27: 1142-1156. https://doi.org/10.1038/cr.2017.98
Ke Huang et al (2017). WIDE AND THICK GRAIN 1, which encodes an otubain-like protease with deubiquitination activity, influences grain size and shape in rice. The Plant Journal; 91(5): 849-860. https://doi.org/10.1111/tpj.13613