Da2 - Seed Size/Yield

Tech ID: 13.561

Key Features

  • Increased seed size, plant growth and grain yield when downregulated together with da1 mutants.


The Da1 gene (PBL Tech ID 07.436) is known to be involved in control of the size of seeds and other plant organs, and ultimately yield, though effects on proliferation and growth of cells.  Mike Bevan and Yunhai Li showed that dominant negative loss-of-function mutations of Da1 caused a marked increase in seed and organ size, and that this effect was synergistic with mutations that abolish the function of the E3 ubiquitin ligase EOD1/BB.  Now, Li (at IGDB, Beijing) and Bevan (JIC) have together found another gene, DA2, which also acts synergistically to control seed/organ size, in a mechanism that is independent of EOD1/BB.

For further detailed information please download the non-confidential summary pdf.


Granted: AU 2014308078; EP 3033354; US 11,519,001; US 10,329,577; ZA 2016/00915

Published: WO2015/022192; EP 3033354; CN 105612171 A; US-2016-0194651-A1; US-2023-0203519-A1


Tian Xia et al (2013).  The Ubiquitin Receptor DA1 Interacts with the E3 Ubiquitin Ligase DA2 to Regulate Seed and Organ Size in ArabidopsisPlant Cell; 25(9): 3347–3359.  https://doi.org/10.1105/tpc.113.115063

Contact: Dr Jan Chojecki

Prof Michael Bevan
John Innes Centre (Norwich, UK)

Dr Yunhai Li
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (Beijing, China)

Related Technology
Tech ID: 07.436 & 13.565 - Da1 Mutant +/- EOD1 - Yield