Tech ID: 13.561
The Da1 gene (PBL Tech ID 07.436) is known to be involved in control of the size of seeds and other plant organs, and ultimately yield, though effects on proliferation and growth of cells. Mike Bevan and Yunhai Li showed that dominant negative loss-of-function mutations of Da1 caused a marked increase in seed and organ size, and that this effect was synergistic with mutations that abolish the function of the E3 ubiquitin ligase EOD1/BB. Now, Li (at IGDB, Beijing) and Bevan (JIC) have together found another gene, DA2, which also acts synergistically to control seed/organ size, in a mechanism that is independent of EOD1/BB.
For further detailed information please download the non-confidential summary pdf.
Granted: AU 2014308078; ZA 2016/00915
Publications: WO2015/022192; EP 3033354; CN 105612171 A; US-2016-0194651-A1
Tian Xia et al (2013). The Ubiquitin Receptor DA1 Interacts with the E3 Ubiquitin Ligase DA2 to Regulate Seed and Organ Size in Arabidopsis. Plant Cell; 25(9): 3347–3359. https://doi.org/10.1105/tpc.113.115063
Contact: Dr Jan Chojecki
Prof Michael Bevan
John Innes Centre (Norwich, UK)
Dr Yunhai Li
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (Beijing, China)
Tech ID: 07.436 & 13.565 - Da1 Mutant +/- EOD1 - Yield