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99.190 - Short RNAs

Patent Reference:
US Patents 6,753,139, 7,704,688, 8,097,710, 8,258,285, 8,263,569, 8,299,235 and 8,349,607. Additional applications pending.

David Baulcombe, Andrew Hamilton
Sainsbury Laboratory (Norwich, UK)

RNA interference or RNAi is rapidly becoming of great importance to mammalian cell research including research on human cells. Professor David Baulcombe and colleagues at the Sainsbury Laboratory, Norwich, UK, were the first to identify a species of target sequence specific small RNAs of between 21 and 25 nucleotides as being diagnostic of RNAi in a range of organisms, including plants. Detection of these short RNAs can be used a s diagnostic tool for correlating the efficiency of silencing of a target gene in any experimental system including the use of RNAi. More importantly siRNAs can also be used to effect gene silencing by introducing siRNAs into organisms to silence specific target genes.


AJ Hamilton and DC Baulcombe (1999).  A species of small antisense RNA in posttranscriptional gene silencing in plants.  Science 286, 950-952.

Please click to see news articles:

Aug 2013 - PBL RNAi partner Dicerna Secures $60 Million in Series C Financing

Apr 2013 - Dicerna and PBL Sign Agreement for Baulcombe & Hamilton RNAi Patents

Mar 2013 - PBL Awarded Further US Patent on Short RNAi Molecules: US 8,349,607

Oct 2012 - PBL Awarded Further US Patent on Short RNAi Molecules: US 8,299,235

Sep 2012 - PBL Awarded Two Further US Patents on RNAi: US 8,258,285 & US 8,263,569

May 2012 - Alnylam and PBL Sign Licence Agreement for Baulcombe & Hamilton RNAi Patent

Jan 2012 - PBL Awarded Pioneering US Patent on RNAi: US 8,097,710

Apr 2010 - PBL Awarded Major US Patent on Short RNA

Contact: Dr Lars von Borcke

Download non-confidential summary (PDF): Click here

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