Tech ID: 99.190
RNA interference or RNAi is rapidly becoming of great importance to mammalian cell research including research on human cells. Professor David Baulcombe and colleagues at the Sainsbury Laboratory, Norwich, UK, were the first to identify a species of target sequence specific small RNAs of between 21 and 25 nucleotides as being diagnostic of RNAi in a range of organisms, including plants. Detection of these short RNAs can be used a s diagnostic tool for correlating the efficiency of silencing of a target gene in any experimental system including the use of RNAi. More importantly siRNAs can also be used to effect gene silencing by introducing siRNAs into organisms to silence specific target genes.
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Granted: US 6,753,139; US 7,704,688; US 8,097,710; US 8,258,285; US 8,263,569; US 8,299,235; US 8,349,607
AJ Hamilton and DC Baulcombe (1999). A species of small antisense RNA in posttranscriptional gene silencing in plants. Science; 286: 950-952. https://doi.org/10.1126/science.286.5441.950