GRF4 Enhanced Crop Nitrogen Use with High Yield

Tech ID: 17.624

Key Features

  • Enhanced Crop Nitrogen Use with High Yield
  • Homoeostatic co-regulation of C/N balance in crops is controlled by GRF4-DELLA interaction
  • Enhanced N-use/uptake and C-assimilation in high-yielding semi-dwarf varieties

Description

Xiangdong Fu and colleagues at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing have found that a growth-regulating factor (GRF4) interacts directly with the DELLA growth inhibitor and this interaction confers homoeostatic co-regulation of carbon/nitrogen balance.  While GRF4 promotes and integrates C-fixation, N-assimilation and cell proliferation, DELLA inhibits them.  Increased GRF4 abundance favours increased C and N assimilation without loss of yield-enhancing dwarfism.  This opens the way to increase the N-use/efficiency of high yielding crops, resulting in major economic and environmental advantages. A range of approaches are possible, including genome editing, and in a range of crop species.

For further detailed information please download the non-confidential summary pdf.

Patents

Published: WO/2019/158911; EP 3751990; CN 111818794A; US 20210071191 A1
Granted: 2020/04855

References

Li et al (2018).  Modulating plant growth–metabolism coordination for sustainable agriculture.  Nature; 560: 595–600.  https://doi.org/10.1038/s41586-018-0415-5

Contact: Dr Jan Chojecki

Inventors
Dr Xiangdong Fu and colleagues
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (Beijing, China)