Increased Seed Size and Grain Yield: GSE5

Tech ID: 17.621

Key Features

  • Increased seed size and grain yield.
  • A role for Calcium-signalling in seed development?
  • Genome editing achieved in rice (Germplasm available), possible in other crops


Dr Yunhai Li and his team at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, have been studying genes involved in determining seed size.  They have identified a novel QTL in rice using a GWAS approach with functional testing. GSE5 encodes a novel plasma membrane-associated protein.  Allelic variation in rice is represented by various deletion/insertion events in the GSE5 promoter.  Reduced expression or loss-of-function of GSE5 results in increased grain width, grain weight and grain yield overall.  This opens the way for increased grain yields using a variety of strategies including genome editing, and in a range of important crop species.

For further detailed information please download the non-confidential summary pdf.


Published: WO/2018/172785; CN 110603264A; EP 3601320; US 2020/0255846; EA 201992261; IN 201917042938A


Duan et al (2017).  Natural variation in the promoter of GSE5 contributes to grain size diversity in rice.  Mol Plant; 10(5): 685-694.

Contact: Dr Jan Chojecki

Dr Yunhai Li and colleagues
Institute of Genetics and Developmental Biology, Chinese Academy of Sciences (Beijing, China)