Tech ID: 17.621
Dr Yunhai Li and his team at the Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, have been studying genes involved in determining seed size. They have identified a novel QTL in rice using a GWAS approach with functional testing. GSE5 encodes a novel plasma membrane-associated protein. Allelic variation in rice is represented by various deletion/insertion events in the GSE5 promoter. Reduced expression or loss-of-function of GSE5 results in increased grain width, grain weight and grain yield overall. This opens the way for increased grain yields using a variety of strategies including genome editing, and in a range of important crop species.
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Published: WO/2018/172785; CN 110603264A; EP 3601320; US 2020/0255846; EA 201992261; IN 201917042938A
Duan et al (2017). Natural variation in the promoter of GSE5 contributes to grain size diversity in rice. Mol Plant; 10(5): 685-694. http://dx.doi.org/10.1016/j.molp.2017.03.009