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02.301 - The Dynamic Gastric Model and The Model Gut

Patent Reference: European Patent EP1907108A1. US Patent US 8,092,222. Australian Patent AU2006271423.

Dr Martin Wickham and Richard Faulks
The Institute for Food Research (Norwich, UK)

The Dynamic Gastric Model (DGM) is a "state of the art" in-vitro system that simulates human gastric digestion, developed at the Institute of Food Research (IFR).  The DGM is the first known in-vitro model developed to combine emerging scientific knowledge of the physical, mechanical and biochemical environments experienced by the luminal contents of the human stomach, in a single predictive system.

PBL is continuing to develop the technology and is seeking potential partners for the manufacture and sale of DGM units into the research and development community.

Please click here to see a video of the Model Gut working.

The Model Gut is a business unit of PBL, established to provide contract research and development services to the Food and Pharmaceutical industries.  Utilising the ground-breaking DGM, the Model Gut provides bio-relevant testing of oral pharmaceutical formulations and novel food structures and products.  The Model Gut business was established as a collaboration between PBL and IFR, operating as a fully commercial entity but integrated with the gut-modelling group within IFR.  The recent transfer of business to the Danish CRO Bioneer A/S provides the Model Gut with a step-change in its capacity to delivery a full-service offering, integrating its proprietary gut simulations with full analytical backup.